Dorsal Hyperintensity and Iron Deposition Patterns in the Substantia Nigra of Early-Onset Parkinsonism: A 7T MRI Study
Motivation: The dorsal nigral hyperintensity (DNH) abnormality is recognized as an imaging characteristic of Parkinson's disease (PD). Goal(s): To assess the utility of DNH abnormality in diagnosis of early-onset Parkinsonism using 7T MRI. Approach: Early-onset PD (EOPD), neurological Wilson's disease (NWD) with parkinsonism, and health controls were recruited to assess the diagnostic performance of DNH abnormality. All underwent 7T T2*-weighted imaging with R2* mapping and principal component analysis performed. Results: The DNH abnormality showed high accuracy in differentiating EOPD from health controls and NWD with parkinsonism. EOPD presented predominant iron deposition in the dorsal and posterior substantia nigra. Impact: The DNH abnormality could aid the diagnosis of EOPD and its differentiation from NWD with parkinsonism. The DNH abnormality may be related to predominant iron deposition in the dorsal and posterior substantia nigra in EOPD.
Authors
- Huizi Ma (ORCID: https://orcid.org/0000-0002-3845-8020)
- Tao Wu (ORCID: https://orcid.org/0000-0002-2400-6509)
- Junhong Zhou (ORCID: https://orcid.org/0000-0002-7931-7646)
- Joyce Ching Mei Lam (ORCID: https://orcid.org/0000-0001-9368-4752)
- Tao Feng (ORCID: https://orcid.org/0000-0002-8530-4622)
- Rui Yan (ORCID: https://orcid.org/0000-0002-8495-1289)
- Ning Wei (ORCID: https://orcid.org/0000-0001-8931-8995)
- Tingyan Yao
- Zhan Wang (ORCID: https://orcid.org/0000-0002-1335-4698)
- Yue Suo (ORCID: https://orcid.org/0000-0002-0632-0262)
- Zhijin Zhang (ORCID: https://orcid.org/0000-0001-8893-2264)
- Dongning Su
- Wei Li (ORCID: https://orcid.org/0000-0001-7430-6019)
- Zhe Zhang (ORCID: https://orcid.org/0000-0001-8220-8443)
- Yuan Li (ORCID: https://orcid.org/0000-0001-5651-819X)
- Jing Jing (ORCID: https://orcid.org/0000-0001-9822-5758)
- Xinyao Liu (ORCID: https://orcid.org/0009-0007-0478-8981)
- Wanlin Zhu (ORCID: https://orcid.org/0000-0002-0525-657X)
- Huiqing Zhao
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4711
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00