The severity of brain changes measured by MR fingerprinting in patients with White Matter Hyperintensities

Motivation: Limited by inefficient and subjective diagnostics for brain white matter abnormalities, we sought to enhance clinical assessments by validating MR Fingerprinting's efficiency in quantifying these issues. Goal(s): To determine if MRF accurately quantifies brain white matter abnormalities in routine clinical settings. Approach: Used MRF to measure T1 and T2 values in 87 patients with white matter abnormalities, comparing them with the performance of T2 FLAIR images Results: Significant differences were observed in relaxation times between white matter inside and outside T2 FLAIR high signal areas, indicating MRF's potential for accurate quantifiable diagnosis of brain white matter abnormalities. Impact: Our study's outcomes can enhance clinical assessments of brain white matter abnormalities. This impacts patients, healthcare providers, and researchers by allowing for more efficient and accurate diagnosis and understanding of previously challenging issues, thereby improving patient care and outcomes.