The clinical application of MR measurement in predicting cerebrospinal fluid pressure in patients with non-small cell lung cancer

Motivation: Patients with NSCLC brain matastasis usually have elevated CSF pressure Goal(s): To assess the diagnostic accuracy of combined ONSD and PCSFV/ICV in diagnosing elevated CSFP. Approach: Both optic nerve and cranial MR scans were performed to measure bilateral ONSD，cranial PCSFV and ICV. Subsequently，CSFP was measured in all patients through lumbar puncture. Results: The average ONSD of bilateral eyes was positively correlated with CSFP（r=0.567，P < 0.001）. PCSFV/ICV was negatively correlated with CSFP（r=-0.365，P=0.003）. Impact: The utilization of MR for measuring ONSD and PCSFV/ICV provides a valuable means to assess variations in CSFP among patients diagnosed with NSCLC⁃LM.