Impact of denoising levels in compressed sensing accelerated MR Elastography on liver stiffness measurement in clinical patients

Motivation: We previously studied compressed sensing(CS) to accelerate standard MRE(sMRE) and evaluated its accuracy on liver fibrosis staging. However, impact of denoising level used in CS on the quantitative method like MRE is unknown Goal(s): To study the impact of different denoising levels in CS on the LS measurement Approach: Quantify LS from three common denoising levels in csMRE and compared it to sMRE in a large cohort of clinical subjects. Results: LS from all three denoising levels have similar accuracy but underestimated higher fibrosis stages. LS confident area with strong denoising increased 34% compared to sMRE. Impact: csMRE shorten breath-hold duration significantly but underestimate the stiffness at higher fibrosis stages. A calibration curve is needed for csMRE to improve accuracy of fibrosis staging. The medium denoising level have a good balance between confident area and LS accuracy.