Spherical Echo-Planar Time-resolved Imaging (sEPTI) for rapid 3D quantitative T2* and susceptibility imaging
Motivation: To improve the quality, resolution, and SNR, and reduce scan time by reducing averages for T2* and QSM at 3T Goal(s): To develop a sEPTI technique that can achieve submillimeter high-quality T2* and QSM quantification in less than 90 seconds. Approach: We developed: (1) an efficient less-correlated spherical EPTI sampling d; (2) an iterative B0 update pipeline for accurate and high SNR B0 map; (3) eddy-current correction to reduce artifacts; (4) a physics-informed unrolled network to boost the SNR. Results: sEPTI achieved whole-brain 0.75-mm T2* and QSM quantification within a 90-second scan with the potential for wide clinical applications. Impact: sEPTI technique was developed with synergetic improvements in sampling, B0 estimation, eddy-current correction, and unrolled-network reconstruction, which achieves whole-brain 0.75-mm distortion-free and blurring-free T2* and QSM quantification at 3T in 90 seconds with the potentials for wide clinical applications.
Authors
- Nan Wang (ORCID: https://orcid.org/0000-0001-8455-530X)
- Congyu Liao (ORCID: https://orcid.org/0000-0003-2270-276X)
- Yannick Brackenier (ORCID: https://orcid.org/0000-0002-9210-5939)
- Siddharth Iyer (ORCID: https://orcid.org/0000-0002-6432-0850)
- Cagan Alkan (ORCID: https://orcid.org/0000-0002-0241-0631)
- Mengze Gao (ORCID: https://orcid.org/0000-0002-2283-9603)
- Daniel P. Abraham (ORCID: https://orcid.org/0000-0003-0402-9620)
- Mark Nishimura (ORCID: https://orcid.org/0000-0003-3976-254X)
- Mahmut Yurt (ORCID: https://orcid.org/0000-0003-3280-4217)
- Adam B. Kerr (ORCID: https://orcid.org/0000-0002-3730-9373)
- Xiaozhi Cao (ORCID: https://orcid.org/0000-0001-5095-648X)
- Kawin Setsompop (ORCID: https://orcid.org/0000-0003-0455-7634)
- Hwihun Jeong (ORCID: https://orcid.org/0000-0002-5711-4290)
- Zihan Zhou (ORCID: https://orcid.org/0000-0002-9034-0951)
- Justin Halda
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0004
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00