Architectural Disruption Signature: Region-specific MRI Biomarkers in Cuprizone-induced Demyelination for Alzheimer’s Disease

Motivation: Demyelination is a key aspect of Alzheimer's disease, with cuprizone mouse models enabling region-specific pathological research. Goal(s): To characterize microstructural differences between SAA and cuprizone-treated SAA mice in isocortex and hippocampal regions using multi-modal MRI. Approach: Analyzed 7 cuprizone-treated vs 7 control male mice using: DWI for DTI, DKI, NODDI metrics across 684 regions, T2* mapping and QSM analysis. Results: Multi-modal MRI analyses revealed significant microstructural alterations in cuprizone-treated mice, including changes in diffusion parameters, and tissue composition across isocortex and hippocampal regions. Impact: This comprehensive multi-modal MRI analysis provides insight into region-specific pathological changes in the cuprizone model, particularly in isocortex and hippocampal areas. These findings enhance our understanding of demyelination processes and could guide the development of targeted therapeutic strategies for AD.