High resolution 3D Deuterium Metabolic Imaging of the human brain using bSSFP with concentric ring trajectory readout at 7T
Motivation: Deuterium metabolic imaging (DMI) suffers from inherently low SNR, which can be enhanced using balanced-steady-state-free-precession (bSSFP) pulse design. Higher SNR can be traded for increased spatial resolution using fast concentric ring trajectory (CRT) sampling. Goal(s): To develop and implement a 3D-bSSFP-DMI sequence for whole-brain DMI in humans at 7T. Approach: A bSSFP sequence module was combined with 3D-CRT sampling and metabolic maps of water/glucose/glutamate+glutamine were dynamically acquired in 4 healthy volunteers. Results: A 2-4-fold SNR increase was observed for DMI maps using bSSFP-DMI compared to FID-CRT-DMI, which allowed for increased spatial resolution (0.75ml to 0.36ml), while maintaining sufficient quality. Impact: Improving SNR and consequently spatial resolution of deuterium metabolic imaging (DMI) data is crucial to push DMI towards clinical application. bSSFP-CRT sequences combined with appropriate reconstruction and metabolite separation can facilitate this transition.
Authors
- Martin Krššák (ORCID: https://orcid.org/0000-0001-9717-803X)
- Rupert R. Lanzenberger (ORCID: https://orcid.org/0000-0003-4641-9539)
- Wolfgang Bogner (ORCID: https://orcid.org/0000-0002-0130-3463)
- Stanislav Motyka (ORCID: https://orcid.org/0000-0002-6314-316X)
- Lukas Hingerl (ORCID: https://orcid.org/0000-0003-1808-8349)
- Elton Tadeu Montrazi (ORCID: https://orcid.org/0000-0001-5898-1153)
- Fabian Niess (ORCID: https://orcid.org/0000-0003-1235-7595)
- Thomas Scherer (ORCID: https://orcid.org/0000-0003-4980-706X)
- Bernhard Strasser (ORCID: https://orcid.org/0000-0001-9542-3855)
- Lucio Frydman (ORCID: https://orcid.org/0000-0001-8208-3521)
- Anna Duguid (ORCID: https://orcid.org/0009-0003-7044-3165)
- Viola Bader (ORCID: https://orcid.org/0009-0004-2393-9579)
- S.D. Frese
- Aaron Osburg (ORCID: https://orcid.org/0009-0001-2622-3355)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0041
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00