Innovation of a bio-approximate magnetic resonance imaging phantom: Approach to optimize relaxation time and proton density

Motivation: The relaxation time of most magnetic resonance phantoms is equivalent to that of the target organ. If the proton density, the differences in which are not discussed, is adjusted, studies can be performed using only phantoms. Goal(s): To develop a phantom with an adjustable proton density and relaxation time equivalent to a living body. Approach: The solvent was a solution of hydrogen peroxide, water, and a carboxy-vinyl polymer. Nickel chloride, trisodium phosphate, and powdered acrylic were used for T1, T2, and proton adjustments, respectively. Results: A phantom was developed with bio-approximate relaxation times and an adjustable proton density. Impact: Phantoms with adjustable relaxation times and proton densities can be studied similarly to imaging a living body. This development is a powerful tool for analyzing performance and image characteristics and can be applied to quantitative MRI evaluation.