Impact of Posture on Brain Volume Assessed with a Rotating 1.5T Cryogen-Free MRI in Healthy Individuals

Motivation: This study aims to examine the clinical implications of postural effects on brain structure. Goal(s): To investigate volumetric differences between upright and supine positions, providing a foundation for future research on how posture affects brain structure. Approach: Thirty-two healthy volunteers were scanned using a cryogen-free 1.5T MRI scanner in supine and upright postures. The 3D T1-MP-RAGE brain images were segmented into 109 regions, and their corresponding volume changes were further evaluated. Results: Most brain regions showed minimal volume change within a ±5% range, indicating structural stability across different postures. These findings provide a basis for future exploration of posture-related impacts on brain structure. Impact: These findings on posture-related brain volume stability may inform future research on the clinical implications of postural effects, enhancing our understanding of brain structure integrity across different positions.