Regional brain function study in patients with primary Sjögren's syndrome Synopsis

Motivation: Primary Sjögren's syndrome (pSS) manifests a spectrum of neuropsychological symptoms, primarily cognitive impairment, but the mechanism of central damage remains unclear. Goal(s): Explore whether pSS patients have abnormal regional brain function changes. Approach: This study combined two regional brain functional indices of rs-fMRI (fALFF and ReHo) and integrated static and dynamic indices to explore the central damage mechanism in pSS patients. Results: Both static (static fALFF, static ReHo) and dynamic (dynamic fALFF, dynamic ReHo) neuroimaging metrics reveal significant alterations in multiple brain regions of pSS patients, with no overlap. Furthermore, some metrics in specific brain regions exhibit a negative correlation with neurocognitive scores. Impact: Our research indicates that static and dynamic indicators have different sensitivities in detecting abnormal activities across various regions, and the combined application of two indicators is more conducive to the comprehensive study of regional brain functional changes in pSS patients.