NOE Imaging of Multiple Sclerosis Subjects at 7T Detects Diffuse Contrast Changes
Motivation: While standard to the diagnosis of multiple sclerosis (MS), conventional structural MRI cannot provide detailed information on changes in lipid metabolism. Goal(s): To utilize NOE imaging to investigate changes between MS and healthy control subjects. Approach: NOE imaging was performed on 15 MS and 10 healthy subjects in conjunction with a multi-pool Lorentzian line fitting model to produce several contrasts including MT, APT, amine, and rNOE. Results: Statistically significant contrast decreases were observed in both the amine (15.3% in NAWM) and rNOE (11.4% in NAWM and 10.6% in NAGM) pools. Impact: This 7T NOE imaging method for patients with MS can provide complementary lipid metabolic information to standard structural imaging and can yield improved diagnostic outcomes for this patient population.
Authors
- Ravi Prakash Reddy Nanga (ORCID: https://orcid.org/0000-0002-3644-5656)
- Ravinder Reddy (ORCID: https://orcid.org/0000-0003-4580-2392)
- Blake Benyard (ORCID: https://orcid.org/0000-0002-2480-4164)
- Matthew K. Schindler (ORCID: https://orcid.org/0000-0003-0157-5669)
- John A. Detre (ORCID: https://orcid.org/0000-0002-8115-6343)
- Anshuman Swain (ORCID: https://orcid.org/0000-0002-0257-8610)
- Paul S. Jacobs (ORCID: https://orcid.org/0000-0003-3566-4010)
- Amit Bar‐Or (ORCID: https://orcid.org/0000-0001-7179-0335)
- Fang Liu (ORCID: https://orcid.org/0000-0003-2922-4414)
- Mark A. Elliott (ORCID: https://orcid.org/0000-0003-4191-5509)
- Madeleine Seitz
- Neil Wilson (ORCID: https://orcid.org/0009-0002-7766-2929)
- Bailey Spangler
- Andi Fu
- Jennifer Orthman-Murphy
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4872
- Primary Topic
- Photoacoustic and Ultrasonic Imaging
- Type
- article
- Field-Weighted Citation Impact
- 0.00