Simultaneous 3-D adiabatic T1rho and quantitative susceptibility mapping for characterization of myocardial infarction in ex vivo mouse
Motivation: Adiabatic T1ρ relaxation time and Quantitative Susceptibility mapping acquired using single imaging sequence are used to determine injured areas in the myocardium after myocardial infarction (MI) Goal(s): The aim was to determine the MI area by acquiring T1ρ relaxation time and quantitative susceptibility maps with one scan. Approach: Mice hearts were imaged ex vivo 14 days after MI by using a T1ρ weighted 3-D gradient‐recalled multi‐echo MRI. Results: Both T1ρ relaxation times and quantitative susceptibility values were altered in the infarcted area compared to the remote area. Impact: This study presents a simultaneous T1ρ and QSM measurement for ex vivo assessment of myocardium after factitious myocardial infarction in mice. The method allowed determination of myocardial infarction based on co-localized 3-D T1ρ relaxation time and quantitative susceptibility maps.
Authors
- Anna‐Kaisa Ruotsalainen (ORCID: https://orcid.org/0000-0002-8512-3768)
- Mikko J. Nissi (ORCID: https://orcid.org/0000-0002-5678-0689)
- Elias Ylä‐Herttuala (ORCID: https://orcid.org/0000-0003-3268-7305)
- Olli Nykänen (ORCID: https://orcid.org/0000-0001-7329-3463)
- Svetlana Laidinen
- Iida Räty (ORCID: https://orcid.org/0009-0005-3938-1984)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/5266
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00