Study on the Differential Diagnostic Value of Cardiac Magnetic Resonance Multiparametric Imaging for Atypical CA and Compensated HHD

Motivation: Atypical cardiac amyloidosis (CA) can be challenging to identify, especially with concurrent hypertension and normal systolic function. Goal(s): This study evaluates the diagnostic value of CMR quantitative parameters in distinguishing atypical CA from compensated hypertensive heart disease (HHD). Approach: In this study, the differences of conventional cardiac function parameters, T1mapping, ECV and myocardial strain in atypical CA, compensatory HHD and normal population were compared. Results: Results show that native T1, ECV, and LV mid-circumferential strain (LVCSMid) have high diagnostic efficacy for differentiating atypical CA from compensated HHD. Impact: This study quantitatively evaluates atypical CA and HHD using T1 mapping and CMR-FT, providing imaging evidence for diagnosis and supporting precision treatment.