Exploring brain microstructure-energy relationships with diffusion MRI and calibrated fMRI measurements
Motivation: MRI is commonly used to study brain function and microstructure separately. A joint study of brain energetics and microstructure can provide a more comprehensive characterization of brain physiology. Goal(s): To explore relationships in grey matter (GM) of brain energy consumption and microstructure markers. Approach: Spatial comparisons in GM were performed between CMRO2, CBF maps (obtained from calibrated fMRI) and microstructure parameters maps, obtained from the Soma-And-Neurite-Density-Imaging (SANDI) model of DWI data. Results: GM CMRO2 was spatially and positively correlated with SANDI's soma radius and density, with a stronger correlation to the former, suggesting that larger cells have higher metabolic demands. Impact: The identified spatial coupling between oxygen consumption and soma size in GM may aid in characterizing the relationship between function and microstructure in the healthy brain.
Authors
- Maria Rita Carriero (ORCID: https://orcid.org/0000-0002-9197-5879)
- Francesca Graziano (ORCID: https://orcid.org/0000-0001-8754-6572)
- Stefano Censi (ORCID: https://orcid.org/0000-0002-3661-7737)
- Antonio Maria Chiarelli (ORCID: https://orcid.org/0000-0002-5347-8417)
- Alessandra Caporale (ORCID: https://orcid.org/0000-0002-2182-8312)
- Valentina Tomassini (ORCID: https://orcid.org/0000-0002-7368-6280)
- Michael Germuska (ORCID: https://orcid.org/0000-0003-0580-4350)
- Ekaterina Bliakharskaia (ORCID: https://orcid.org/0009-0007-5943-9586)
- Emma Biondetti (ORCID: https://orcid.org/0000-0001-6727-0935)
- Richard G. Wise (ORCID: https://orcid.org/0000-0003-1700-2144)
- Marco Palombo (ORCID: https://orcid.org/0000-0003-4892-7967)
- Davide Di Censo (ORCID: https://orcid.org/0000-0001-6116-607X)
- Sara Pomante
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4870
- Primary Topic
- Advanced Neuroimaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00