1H MR spectroscopy to evaluate the effects of lonidamine and temozolomide treatment in a mouse model of glioblastoma
Motivation: To develop an alternate effective therapy for treating glioblastomas. Goal(s): To assess metabolic changes as therapeutic indices of treatment response to Lonidamine (LND)and temozolomide (TMZ) against glioblastoma (GBM). Approach: C57BL6 mice implanted with GL261 GBM cells were treated with saline or LND+TMZ. Metabolic changes were monitored using longitudinal MRS. Results: Significant reductions in lactate, tCho/NAA, Lip+Lac/tCr and mI/tCr ratios, were observed post-treatment, suggesting early indicators of treatment response. Impact: This combination therapy might be a suitable alternative for better treatment of glioblastomas.
Authors
- Tareq Alrashidi
- Harish Poptani (ORCID: https://orcid.org/0000-0002-0593-3235)
- Stephen Pickup (ORCID: https://orcid.org/0000-0002-7016-8648)
- Elisabeth Non Gash (ORCID: https://orcid.org/0000-0002-6415-3335)
- Christopher B. Ball (ORCID: https://orcid.org/0000-0002-5983-1605)
- Sourav Bhaduri (ORCID: https://orcid.org/0000-0001-9935-835X)
- Mahon L. Maguire
- Mohesh Moothanchery
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4920
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00