Neuroimaging-Based Glymphatic Function Predicts Conversion from Prodromal to Manifest Parkinson's Disease

Motivation: Uncertain role of glymphatic system in pPD and its effect on PD transition. Goal(s): Study aims to evaluate glymphatic system changes and PD conversion link in pPD group. Approach: The study evaluated glymphatic function in pPD, new PD, and controls, and assessed the DTI-ALPS index's predictive power for PD conversion risk in pPD participants. Results: pPD and ndPD groups had lower DTI-ALPS index than HC. pPD participants converted to PD, with risk inversely linked to theDTI-ALPS index. Impact: The DTI-ALPS index indicates glymphatic dysfunction in pPD and predicts conversion to PD, aiding early risk assessment and intervention.