Age and sex-related changes of the GSH level of the striatum in healthy individuals as revealed with proton magnetic resonance spectroscopy
Motivation: The glutathione (GSH) depletion and/or alterations in its metabolism in the brain are closely related to neurodegeneration diseases especially the pathogenesis of Parkinson's disease. Goal(s): To characterize the effect of age and sex on the GSH in striatum in normal controls. Approach: Taking advantage of proton magnetic resonance spectroscopy (1H-MRS) with MEscher-Garwood Point RESolved Spectroscopy (MEGA-PRESS) to detect GSH levels in specific brain regions. Results: In healthy populations (age range: 21-77 years), GSH levels in the left striatum showed a negative correlation with age. Impact: This study offered a baseline of GSH level in the striatum which provided a reference for further research regarding the degree of oxidative stress.
Authors
- Peng Wu (ORCID: https://orcid.org/0000-0001-6293-2653)
- Naying He (ORCID: https://orcid.org/0000-0002-5477-8120)
- Jinyuan Weng (ORCID: https://orcid.org/0000-0003-1593-9312)
- Fuhua Yan (ORCID: https://orcid.org/0000-0002-5910-1506)
- Youmin Zhang (ORCID: https://orcid.org/0000-0002-9731-5943)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/1791
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00