Voxelwise T2 Corrected Multi-TE ASL in Meningiomas: Initial Experience
Motivation: The multi-TE ASL method could assess tumor permeability in meningiomas. Standard quantification of multi-TE ASL requires a global transverse relaxation time (T2) value, which might lead to suboptimal perfusion estimations at tumor region. Goal(s): To evaluate tumor permeability in meningiomas using multi-TE ASL with voxelwise T2 estimates. Approach: Multi-TE ASL data were acquired in six meningioma patients. Mono-exponentially fitted T2 maps were used in the multi-TE ASL data processing to estimate water exchange (Tex) and perfusion (CBF) maps using ExploreASL. Results: Lower Tex in the tumor region and normal-appearing gray matter (NAGM) and higher Tex in the normal-appearing white matter (NAWM) were observed. Impact: This study demonstrated that multi-TE ASL incorporating voxelwise T2 values can measure CBF and Tex in meningiomas to assess tumor permeability.
Authors
- Alp Di̇nçer (ORCID: https://orcid.org/0000-0001-9158-8353)
- Klaus Eickel (ORCID: https://orcid.org/0000-0002-5700-2029)
- Simon Konstandin (ORCID: https://orcid.org/0000-0002-8143-2221)
- Vera C. Keil (ORCID: https://orcid.org/0000-0001-8699-3506)
- Nora-Josefin Breutigam (ORCID: https://orcid.org/0000-0002-8528-9792)
- Daniel Hoinkiss (ORCID: https://orcid.org/0000-0002-3358-7296)
- Henk J. M. M. Mutsaerts (ORCID: https://orcid.org/0000-0003-0894-0307)
- Amnah Mahroo (ORCID: https://orcid.org/0009-0005-8480-0965)
- Ayça Erşen-Danyeli
- Esin Öztürk-Işık (ORCID: https://orcid.org/0000-0002-8997-878X)
- Koray Özduman (ORCID: https://orcid.org/0000-0002-3543-0401)
- Jan Petr (ORCID: https://orcid.org/0000-0002-3201-6002)
- Beatriz Padrela (ORCID: https://orcid.org/0000-0001-6836-9443)
- Ayşe İrem Çetin (ORCID: https://orcid.org/0000-0002-9298-0565)
- Gülce Turhan (ORCID: https://orcid.org/0000-0003-2645-8442)
- Matthias Günther (ORCID: https://orcid.org/0000-0002-2650-7956)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3257
- Primary Topic
- Meningioma and schwannoma management
- Type
- article
- Field-Weighted Citation Impact
- 0.00