Investigating Abnormal Glymphatic Function and Perivascular Space in Alzheimer’s Disease Using Dynamic Contrast-Enhanced MRI and DTI-ALPS

Motivation: The correlation between glymphatic function and perivascular space (PVS) remains unclear in Alzheimer's disease (AD). Goal(s): To investigate the relationship between glymphatic function and PVS in AD animal model. Approach: Dynamic contrast-enhanced MRI (DCE-MRI) and diffusion tensor imaging (DTI) were used to investigate the difference of perfusion function and PVS between wild-type (WT) and AD group. Results: Larger ratio of DTI-ALPS and weaker glymphatic function were found in AD group. Impact: This study reveals the relationship between glymphatic function and PVS in AD animal model.