Multi-center and multi-vendor phantom study on ADC accuracy, repeatability and reproducibility across 1.5T and 3T MRI scanners
Motivation: Apparent diffusion coefficient (ADC) is a promising imaging biomarker for tissue characterization, particularly in renal applications. However, diffusion metrics variation across scanners poses challenges for multi-center studies. Goal(s): Our aim was to demonstrate the feasibility of QIBA validation process for ADC measurements in abdominal setups at 1.5T and 3T across multiple sites and vendors. Approach: In six sites, ADC values were measured on the QIBA/NIST diffusion phantom and compared to reference values, adjusting for temperature. Results: Excellent accuracy, repeatability and reproducibility were found, especially in the renal range. Despite some differences across field strengths and vendors the overall inter-scanner agreement was excellent. Impact: Implementing the QIBA validation process, using standardized protocols across sites and vendors, for diffusion measurements is feasibile in abdominal setups at both 1.5T and 3T. This is a crucial step to enhance reliability in multi-center renal MRI studies.
Authors
- Anika Strittmatter (ORCID: https://orcid.org/0000-0002-6184-8481)
- Rebeca Echeverría‐Chasco (ORCID: https://orcid.org/0000-0003-0199-2593)
- María A. Fernández‐Seara (ORCID: https://orcid.org/0000-0001-8536-6295)
- Steffen Ringgaard (ORCID: https://orcid.org/0000-0001-5353-7379)
- Anna Caroli (ORCID: https://orcid.org/0000-0002-4130-4663)
- Michela Bozzetto (ORCID: https://orcid.org/0000-0002-2045-5550)
- Susan Francis (ORCID: https://orcid.org/0000-0003-0903-7507)
- Luisa Pierotti
- Anish Raj (ORCID: https://orcid.org/0000-0003-0036-0228)
- Esben Søvsø Szocska Hansen (ORCID: https://orcid.org/0000-0001-5512-9870)
- Christoffer Laustsen (ORCID: https://orcid.org/0000-0002-0317-2911)
- Matteo Renzulli (ORCID: https://orcid.org/0000-0002-1311-5670)
- Leyre García-Ruiz (ORCID: https://orcid.org/0000-0002-2019-2885)
- Giulia Villa (ORCID: https://orcid.org/0000-0003-1120-9638)
- Paolo Brambilla (ORCID: https://orcid.org/0000-0002-6809-1178)
- Malene Aastrup (ORCID: https://orcid.org/0009-0005-0728-3167)
- Siria Pasini (ORCID: https://orcid.org/0009-0009-6879-3805)
- Frank G. Zoellner
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3638
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00