Glymphatic Alterations Mediate Cognitive Dysfunction in Relapsing-Remitting Multiple Sclerosis
Motivation: Identifying more MRI biomarkers is needed to better understand the pathological processes responsible for relapsing-remitting multiple sclerosis (RRMS)-related cognitive impairment (Co-I). Goal(s): To investigate the association between choroid plexus volume (CPV) and cognition in RRMS and analyze whether it was mediated by the glymphatic function. Approach: 60 MS patients and 44 healthy controls were enrolled. DTI-ALPS indexes were calculated. Correlations between DTI-ALPS and CPV and cognitive performance were analyzed. Results: RRMS patients with Co-I showed lower ALPS-index and higher CP volume. ALPS-index mediated the effect of enlarged CP on cognitive function. Impact: The impact of enlarged CP on cognitive function is mediated by glymphatic alterations, indicating a pathological mechanism for MS-related cognitive impairment.
Authors
- Kai Ai (ORCID: https://orcid.org/0000-0002-7326-0706)
- Jing Zhang (ORCID: https://orcid.org/0000-0003-2541-4923)
- Wei Ren (ORCID: https://orcid.org/0000-0001-8590-1737)
- Xia Xu (ORCID: https://orcid.org/0000-0002-1982-7062)
- Zhuo Wang (ORCID: https://orcid.org/0000-0001-9997-3109)
- Jinrui Liu (ORCID: https://orcid.org/0000-0003-0778-4701)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3753
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00