Common Neural Patterns of Substance Use Disorder: A Seed-based Resting-State Functional Connectivity Meta-Analysis

Motivation: The changes in cortical-striatal-thalamic-cortical functional connectivity patterns may be a common neural mechanism in substance addicted patients. Goal(s): The present study aim to identify common neural patterns in patients with substance use disorder. Approach: The seed-based D-mapping toolkit was used to analyzed connectivity patterns in key brain regions of the reward circuit, including the anterior cingulate cortex, prefrontal cortex, striatum, thalamus, and amygdala. Results: The present study identifies disruptions in two critical reward circuits: the cortical-striatal-thalamic-cortical circuit and the cortical-striatal-hippocampus/parahippocampal gyrus-amygdala-cortical circuit. Impact: All substance use disorder individuals have the same neural mechanism, which is the disruption of reward circuits.