Mapping Hand Function in the Brain and Spinal Cord with Simultaneous Brain-Spinal Cord Functional MRI
Motivation: Hand function can be disrupted by injury to the brain, SC, and peripheral nerves leading to weakness and impaired coordination. With simultaneous brain-spinal cord (SC) fMRI, we can non-invasively assess the neural mechanisms underlying motor control of the hand. Goal(s): Map brain and SC activity to improve our understanding of the neural correlates of hand function. Approach: Simultaneous brain-SC fMRI was performed on twenty-eight healthy volunteers during force matching and finger tapping experiments with three task levels. Results: Graded brain and SC activity across the task levels was identified, including activation and deactivation of sensory and motor regions. Impact: We mapped brain and SC neural correlates of hand function showing activations and deactivations in sensory and motor regions, providing a more complete picture of motor control.
Authors
- Sean Mackey (ORCID: https://orcid.org/0000-0001-7744-5348)
- Gary H. Glover (ORCID: https://orcid.org/0000-0002-0562-0474)
- Valeria Oliva (ORCID: https://orcid.org/0000-0001-7849-191X)
- Dario Pfyffer (ORCID: https://orcid.org/0000-0002-2406-9251)
- Christine Law (ORCID: https://orcid.org/0000-0003-0524-6029)
- Merve Kaptan (ORCID: https://orcid.org/0000-0001-8187-4911)
- Kenneth A. Weber (ORCID: https://orcid.org/0000-0002-0916-9174)
- Sandrine Bédard (ORCID: https://orcid.org/0000-0001-9859-1133)
- Scott L. Delp (ORCID: https://orcid.org/0000-0002-9643-7551)
- Trevor Hastie (ORCID: https://orcid.org/0000-0002-0164-3142)
- Zachary A. Smith (ORCID: https://orcid.org/0000-0003-2130-8592)
- John K. Ratliff (ORCID: https://orcid.org/0000-0003-3452-1907)
- Serena S. Hu (ORCID: https://orcid.org/0000-0001-8912-4277)
- Akshay Sanjay Chaudhari (ORCID: https://orcid.org/0000-0002-3667-6796)
- Andrew Smith (ORCID: https://orcid.org/0000-0001-7111-3625)
- Nazrawit Berhe
- Brett Chy
- Susanna Aufrichtig
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0208
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00