Orientation Dependence of MRF-Derived qMRI Parameters in Human Articular Cartilage
Motivation: To study the orientation dependence of MRF-derived qMRI parameters in human articular cartilage at clinical field strength. Goal(s): Measure and compare the orientation dependencies of T1 and T2 relaxation times determined with conventional and MRF sequences on a clinical 3 T MRI scanner. Approach: Human cartilage samples (N=96) were imaged using conventional qMRI sequences and MRF at two orientations with respect to the main magnetic field. Results: Both the conventional method and MRF yielded similar T2 values in cartilage along with notable orientation dependencies of similar strength. T1 values were similar between the conventional method and MRF and showed no notable orientation dependence. Impact: Improving the reliability of parametric mapping using MRF can lead to a significant scan time reduction, improving the throughput of examination in a clinical setting.
Authors
- Riccardo Lattanzi (ORCID: https://orcid.org/0000-0002-8240-5903)
- Michael Werner (ORCID: https://orcid.org/0000-0002-7864-9446)
- Martijn A. Cloos (ORCID: https://orcid.org/0000-0002-0636-234X)
- Mikko J. Nissi (ORCID: https://orcid.org/0000-0002-5678-0689)
- Simo Saarakkala (ORCID: https://orcid.org/0000-0003-2850-5484)
- Miika T. Nieminen (ORCID: https://orcid.org/0000-0002-2300-2848)
- Victor Casula (ORCID: https://orcid.org/0000-0003-0447-2796)
- Martin Englund (ORCID: https://orcid.org/0000-0003-3320-2437)
- Ville Kantola (ORCID: https://orcid.org/0000-0001-9584-7500)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2951
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00