7T MRSI ratios can predict the presence of 5-ALA fluorescence in gliomas comparable to T1w-CE and PET
Motivation: The role of MRSI in predicting 5-ALA fluorescence in gliomas has not yet been explored. Goal(s): Our goal was to test if 7T MRSI is able to predict the presence of 5-ALA fluorescence and to compare it to CE MRI and PET. Approach: We retrospectively evaluated 5-ALA fluorescence, 7T MRSI ratio levels, PET TNRs and T1w-CE in 30 glioma patients. Further, we tested their abilities to predict 5-ALA fluorescence using ROC curves. Results: ROC curves indicate that Gln/tCr, Gly/tCr, Ser/tCr and GSH/tCr have the potential to predict 5-ALA fluorescence, with performance comparable to CE and PET. Impact: Our results show that 7T MRSI is a powerful tool for predicting 5-ALA fluorescence in gliomas and can be useful in therapy planning. It would be valuable to investigate the spatial correlation between 7T MRSI and areas of 5-ALA fluorescence.
Authors
- Cornelius Cadrien (ORCID: https://orcid.org/0000-0002-0341-2209)
- Karl Roessler (ORCID: https://orcid.org/0000-0002-9249-8082)
- Günther Grabner (ORCID: https://orcid.org/0000-0001-8330-8446)
- Siegfried Trattnig (ORCID: https://orcid.org/0000-0003-1623-3303)
- Tatjana Traub‐Weidinger (ORCID: https://orcid.org/0000-0003-1118-926X)
- Wolfgang Bogner (ORCID: https://orcid.org/0000-0002-0130-3463)
- Johannes Leitner
- Julia Furtner (ORCID: https://orcid.org/0000-0001-8258-3681)
- Thomas Roetzer-Pejrimovsky (ORCID: https://orcid.org/0000-0001-8875-7304)
- Gilbert Hangel (ORCID: https://orcid.org/0000-0002-3986-3159)
- Matthias Preusser (ORCID: https://orcid.org/0000-0003-3541-2315)
- Georg Widhalm (ORCID: https://orcid.org/0000-0001-6014-0273)
- Philipp Lazen (ORCID: https://orcid.org/0000-0002-9952-3084)
- Nicolas Weilguny
- Sara Huskić
- Anita Kloss-Brandstaetter
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0075
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00