MRI imaging of myelin and iron in Huntington’s Disease
Motivation: Huntington's disease (HD) is characterized by myelin damage and iron accumulation. Robust detection of myelin and iron is critical. Goal(s): To apply a series of MRI techniques to detect myelin and iron changes in HD. Approach: A 3D Short TR Adiabatic Inversion Recovery UTE (STAIR-UTE) sequence for Myelin Proton Fraction (MPF) mapping, UTE Quantitative Susceptibility Mapping (UTE-QSM) sequence for iron mapping, divided Subtracted Inversion Recovery (dSIR) sequence for morphological imaging, and synthetic MRI have been applied to HD (n=7) and control (n=7) population. Results: People with HD show significant myelin loss in white matter and iron accumulation in gray matter over control subjects. Impact: The STAIR-UTE, UTE-QSM and dSIR techniques can detect myelin loss, iron accumulation, and morphological changes in HD, respectively, and may help with early diagnosis and treatment monitoring of HD.
Authors
- Jody Corey‐Bloom (ORCID: https://orcid.org/0000-0001-9790-8610)
- Graeme M. Bydder (ORCID: https://orcid.org/0000-0002-8468-0087)
- Soo Hyun Shin (ORCID: https://orcid.org/0000-0003-1875-2908)
- Jiyo Athertya (ORCID: https://orcid.org/0000-0002-0866-1052)
- James Lo (ORCID: https://orcid.org/0000-0002-7351-0752)
- Yajun Ma
- Haiying Tang
- Krisha Bagga
- Jiang Du
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2983
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00