Effect of Pregnancy on MRI measures of Kidney and Liver Cyst Growth Rates in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Motivation: There is limited knowledge about pregnancy effects on renal and hepatic cyst growth in ADPKD. Goal(s): To assess if renal and hepatic cyst growth rate during pregnancy is greater among ADPKD patients as compared to a non-ADPKD control group. Approach: We used MRI scans to measure and compare total kidney and liver volume and cyst growth rates during and during non-pregnancy in 16 ADPKD patients, including subgroup analysis based on IVF status. Results: Pregnancy was associated with increased kidney growth rate and a trend of cysts growing faster. Liver increased trend of growth in pregnancy was similar to non-ADPKD controls. Impact: Female ADPKD patient should consider the risk of increase kidney growth prior to pregnancy.
Authors
- Vahid Bazojoo (ORCID: https://orcid.org/0009-0006-7702-8898)
- Jon D. Blumenfeld (ORCID: https://orcid.org/0000-0001-6230-4067)
- Arman Sharbatdaran (ORCID: https://orcid.org/0000-0002-7097-0032)
- Grace C. Lo (ORCID: https://orcid.org/0000-0002-3564-0660)
- Martin R. Prince (ORCID: https://orcid.org/0000-0002-9883-0584)
- Hreedi Dev (ORCID: https://orcid.org/0000-0002-5341-8350)
- James M. Chevalier (ORCID: https://orcid.org/0000-0002-1376-4099)
- Line Malha (ORCID: https://orcid.org/0000-0003-1980-7798)
- Zhongxiu Hu (ORCID: https://orcid.org/0009-0009-9258-5459)
- Mina C. Moghadam
- Vahid Davoudi (ORCID: https://orcid.org/0009-0009-3468-9938)
- Usama Sattar (ORCID: https://orcid.org/0009-0005-0114-3235)
- Yin Wang
- Xinzi He (ORCID: https://orcid.org/0000-0003-4492-7695)
- Chenglin Zhu (ORCID: https://orcid.org/0009-0003-6662-4908)
- Syed Raza (ORCID: https://orcid.org/0009-0000-7511-0106)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/2707
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00