Fingerprint of in vivo histology MRI in drug-resistant temporal lobe epilepsy patients
Motivation: In drug-resistant temporal-lobe epilepsy (dTLE) clear identification of lesions in standard clinical MRI is advantageous for successful surgical planning, but non-invasive access to microstructure via in-vivo histology MRI (hMRI) remains unassessed. Goal(s): To test whether the hMRI fingerprint reveals information beyond standard clinical MRI in neurosurgery target regions. Approach: In two patients (one MR-atrophic, the other MR-hyperintense), we used interhemispheric differences as a proxy for asymmetric dTLE-relevant abnormalities and assess their profile across hMRI metrics. We tested consistency of hMRI fingerprints across patients. Results: hMRI fingerprint shows a significant correlation across patients in the amygdala, with a stronger profile in the MR-hyperintense patient. Impact: Novel MRI contrasts can improve our understanding of lesion microstructure in epilepsy. This study shows consistent fingerprints of hMRI metrics across two patients with different MR-clinical findings, indicating that hMRI might complement clinical MRI by revealing information about tissue microstructure.
Authors
- John Oeschger
- Thomas Sauvigny (ORCID: https://orcid.org/0000-0002-8363-9576)
- Arthur Chakwizira (ORCID: https://orcid.org/0000-0002-2735-7304)
- Nikolaus Weiskopf (ORCID: https://orcid.org/0000-0001-5239-1881)
- Markus Nilsson (ORCID: https://orcid.org/0000-0002-3140-8223)
- Francisco J. Fritz (ORCID: https://orcid.org/0000-0002-6506-6508)
- José P. Marques (ORCID: https://orcid.org/0000-0001-8157-8864)
- David G. Carmichael (ORCID: https://orcid.org/0000-0002-2941-3488)
- Ileana Jelescu (ORCID: https://orcid.org/0000-0002-3664-0195)
- Martina F. Callaghan (ORCID: https://orcid.org/0000-0003-0374-1659)
- Filip Szczepankiewicz (ORCID: https://orcid.org/0000-0002-5251-587X)
- Björn Fricke (ORCID: https://orcid.org/0009-0007-7087-2604)
- Laurin Mordhorst (ORCID: https://orcid.org/0000-0001-9870-3916)
- Siawoosh Mohammadi (ORCID: https://orcid.org/0000-0003-1311-9636)
- Ora Ohana (ORCID: https://orcid.org/0000-0002-4192-0626)
- Nina Lüthi
- Noémie Sura
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3540
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00