Spectrally selective and interleaved water imaging and fat imaging (siWIFI) with fat peak correction

Motivation: Water-fat separation and quantification are of critical importance in the MRI assessment of diseases involving fat infiltration. Goal(s): To develop a robust and reliable fat quantification method. Approach: We designed a novel sequence for spectrally selective and interleaved water imaging and fat imaging (siWIFI). We also scaled the acquired images to account for the unselected fat peaks around the water. The sequence was tested in the hip, knee, and liver of healthy volunteers. Results: The fat quantification via siWIFI was improved with fat peak correction. Fat quantifications from subjects were comparable to those from IDEAL scans and were robust against typical B0 inhomogeneity. Impact: siWIFI selectively images water and fat, achieving accurate fat quantification with a simple fat peak correction. This method is expected to provide robust and accurate fat quantification for monitoring diseases involving fat infiltration and metabolic disruption.