Tractography-informed estimation of local axonal damage in multiple sclerosis
Motivation: Assessing myelin damage in multiple sclerosis (MS) is essential, as it can yield crucial insights into disease mechanisms. Goal(s): This work provides a novel method to assess myelin damage in MS, offering detailed information that outperforms traditional measures. Approach: We extended a microstructure-informed tractography framework by adding an ad-hoc compartment that explicitly models potential myelin loss of the fiber tracts affected by lesions. Results: The estimated myelin loss significantly correlates with motor disability and disease progression, enhancing our understanding of demyelination in MS pathology. Impact: In this work, we used an innovative method to compute myelin loss, providing insight that a standard myelin-sensitive map couldn't provide. These values significantly correlate with motor disability and disease progression, enhancing our understanding of MS pathology and treatment effects.
Authors
- Xinjie Chen (ORCID: https://orcid.org/0000-0002-3683-6489)
- Nina de Oliveira S. Siebenborn
- Sara Bosticardo (ORCID: https://orcid.org/0000-0002-0063-2521)
- Alessandro Daducci (ORCID: https://orcid.org/0000-0002-4677-6678)
- Alessandro Cagol (ORCID: https://orcid.org/0000-0002-7703-0553)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Po‐Jui Lu (ORCID: https://orcid.org/0000-0001-6031-6865)
- Ludwig Kappos (ORCID: https://orcid.org/0000-0003-4175-5509)
- Matthias Weigel (ORCID: https://orcid.org/0000-0002-4910-1414)
- Esther Ruberte (ORCID: https://orcid.org/0000-0002-0195-4602)
- Matteo Battocchio
- Mario Ocampo‐Pineda (ORCID: https://orcid.org/0000-0003-2239-7355)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Lester Melie‐García (ORCID: https://orcid.org/0000-0001-5602-8916)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/4083
- Primary Topic
- Cell Image Analysis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00