First observation in a human of real-time BOLD-fMRI response to epileptic seizure

Motivation: While the potential of fMRI to localize the seizure onset zone (SOZ) and epileptic networks has been widely described, BOLD response to an epileptic seizure has not been previously reported. Goal(s): To provide the first description of the real-time BOLD response to an epileptic seizure and characterize its evolution with respect to the timeseries of the SOZ. Approach: We applied independent component analysis and cross-correlation on resting-state fMRI data acquired during a seizure in a patient with temporal epilepsy. Results: The SOZ BOLD peaked after ~19s from seizure onset. A simultaneous propagation network was identified. Other brain networks had anti-correlated and delayed evolution. Impact: This is the first description of real-time BOLD response to an in-scanner epileptic seizure in a human and improves our knowledge on the mechanisms of brain function following such events.

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Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2025-09-16
DOI
https://doi.org/10.58530/2025/0136
Primary Topic
Functional Brain Connectivity Studies
Type
article
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article

First observation in a human of real-time BOLD-fMRI response to epileptic seizure

Lorenzo Ferri, Elena Pasini, Caterina Tonon, Raffaele Lodi et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Functional Brain Connectivity Studies
article

First observation in a human of real-time BOLD-fMRI response to epileptic seizure

Lorenzo Ferri, Elena Pasini, Caterina Tonon, Raffaele Lodi, Matteo Martinoni, David Neil Manners, Gianfranco Vornetti, Giovanni Sighinolfi, Elena Cantoni, Roberto Michelucci
article en

Abstract

Motivation: While the potential of fMRI to localize the seizure onset zone (SOZ) and epileptic networks has been widely described, BOLD response to an epileptic seizure has not been previously reported. Goal(s): To provide the first description of the real-time BOLD response to an epileptic seizure and characterize its evolution with respect to the timeseries of the SOZ. Approach: We applied independent component analysis and cross-correlation on resting-state fMRI data acquired during a seizure in a patient with temporal epilepsy. Results: The SOZ BOLD peaked after ~19s from seizure onset. A simultaneous propagation network was identified. Other brain networks had anti-correlated and delayed evolution. Impact: This is the first description of real-time BOLD response to an in-scanner epileptic seizure in a human and improves our knowledge on the mechanisms of brain function following such events.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 75%
Functional Brain Connectivity Studies
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First observation in a human of real-time BOLD-fMRI response to epileptic seizure — Lorenzo Ferri, Elena Pasini, et al. · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2025) | TGRS Research Map | TGRS