Prognostic impact of epicardial adipose tissue and cardiac magnetic resonance left atrial strain analysis in patients with heart failure with preserved ejection fraction

Motivation: The pathogenesis of HFpEF and the risk factors affecting its prognosis remain poorly understood. Goal(s): Exploring the value of EAT and left atrial strain in predicting heart failure and adverse prognosis in patients with heart failure with preserved ejection fraction. Approach: The epicardial adipose tissue (EAT), the three LA phasic strains, as well as the left ventricular longitudinal, radial, and circumferential strains were calculated with CVI42. Results: The three LA strains are indicators for evaluating adverse prognosis in patients with HFpEF. EAT and global longitudinal strain are indicators for predicting heart failure; however, they did not demonstrate an advantage in predicting adverse prognosis. Impact: Our research elucidates that increased EAT thickness in patients with HFpEF suggests o left ventricular dysfunction, while early abnormalities in LA function can serve as a predictor of adverse prognosis.