Quantification of myocardial oxygen consumption and myocardial external efficiency using cardiac MRI: a pilot study in post-MI HFrEF patients
Motivation: Myocardial external efficiency (MEE) relating the left ventricular (LV) mechanical energetic output to myocardial oxidative metabolism demonstrates the efficiency of LV performance. Goal(s): Explore the feasibility of a newly developed non-invasive and radiation-free cardiac magnetic resonance (CMR) technique for MEE in patients with heart failure (HF) following myocardial infarction (MI). Approach: A prospective single institutional study enrolling post-MI HF patients and control subjects who received a high-resolution, non-ECG gated and free-breathing GRE T2-weighted inversion recovery MR oximetry sequence. Results: MEE derived by CMR demonstrated moderate correlations between EF and myocardial strain and was lower in patients compared to control subjects. Impact: The non-invasive and radiation-free GRE T2-weighted inversion recovery CMR technique can evaluate myocardial oxidative embolism and assess myocardial performance efficiency, which is lower in post-MI HF patients.
Authors
- Chia-Chi Yang (ORCID: https://orcid.org/0000-0003-0933-7067)
- Alan C. Kwan (ORCID: https://orcid.org/0000-0002-4393-1011)
- Hao Ho (ORCID: https://orcid.org/0000-0001-8911-7907)
- Henghui Zhang (ORCID: https://orcid.org/0000-0002-2820-7447)
- Ghazal Yoosefian
- Janet Wei (ORCID: https://orcid.org/0000-0002-1311-618X)
- Xinqi Li (ORCID: https://orcid.org/0009-0002-4799-8333)
- Jeremy Zepeda (ORCID: https://orcid.org/0000-0001-8955-2992)
- Xinheng Zhang (ORCID: https://orcid.org/0000-0001-6409-3160)
- C. Noel Bairey Merz (ORCID: https://orcid.org/0000-0002-9933-5155)
- Rohan Dharmakumar (ORCID: https://orcid.org/0000-0003-4120-4635)
- Archana Malagi (ORCID: https://orcid.org/0000-0002-2332-170X)
- Guan Wang (ORCID: https://orcid.org/0000-0002-2932-0791)
- Ranran Zhang (ORCID: https://orcid.org/0000-0002-0394-3245)
- Yuheng Huang (ORCID: https://orcid.org/0000-0002-5358-4826)
- Hsin‐Jung Yang (ORCID: https://orcid.org/0000-0001-9379-5495)
- Xiaoming Bi
- Li-Ting Huang
- Anthony Christodoulou (ORCID: https://orcid.org/0000-0002-9334-8684)
- Michael D Nelson
- Debiao Li
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0356
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00