68Ga-NaGdF4-RGD nanoprobes for PET/MR Dual-Modal Imaging of cancer in Vivo

Motivation: There are still rare multi-modality contrast agents or probes that can enhance both the signals of PET and MRI synchronously in clinical. Goal(s): We developed a strategy of synchronous PET/MR diagnosis of tumor based on 68Ga-NaGdF4@RGD nanoprobes. Approach: The in vivo PET/MR multimodal simultaneous imaging capability of 68Ga-NaGdF4-RGD nanoparticles was validated by a wider variety of tumor models. Additionally, the relationship between the targeting effect and integrin αvβ3 expression levels was explored. Results: The fact suggested that 68Ga-NaGdF4-RGD probes possessed satisfying tumor-specific targeting ability . The level of enrichment of the nanoprobes was found to reflect the expression level of integrin αvβ3 in tumors. Impact: This study successfully achieved simultaneous PET/MR multimodal imaging, which significantly improves the diagnostic accuracy of tumour. The radioactivity uptake of can reflect the integrin αvβ3 expression level of the tumour, and PET/MR is expected to be used for tumour staging.