Early detection of cell death using transmembrane water exchange MRI
Motivation: Early detection of cell death with FEXI. Goal(s): Investigate the sensitivity of AXR measurements to tumor cell death after therapy. Approach: Evaluate FEXI, DWI, hyperpolarized malate/fumarate CSI, H&E histology, and fluorescence imaging in preclinical tumors. Compare FEXI and DWI for clinical uterine fibroids therapy response assessment. Results: AXRs and malate/fumarate ratios correlate, but not with ADC, in solid-growing EL4 lymphoma in mice. FEXI and DWI of EL4 lymphoma treated with etoposide or Colo205 colorectal carcinoma treated with a TRAILR2 agonist had increased AXR. Clinical FEXI shows sensitivity to embolization after 24 hours. Impact: Transmembrane water permeability measured by AXR is a sensitive marker for cell death during cancer progression or therapy. FEXI is a contrast agent-free technique that can be easily included in clinical MR protocols.
Authors
- Katja Steiger (ORCID: https://orcid.org/0000-0002-7269-5433)
- Julian Rauch
- Simone Ballke (ORCID: https://orcid.org/0000-0001-6586-2099)
- Kevin Michael Brindle (ORCID: https://orcid.org/0000-0003-3883-6287)
- Philipp M. Paprottka (ORCID: https://orcid.org/0000-0001-5047-4659)
- Geoffrey J. Topping
- Athanasia Kaika
- Mathias Schillmaier
- Sandra Sühnel
- Luca Nagel (ORCID: https://orcid.org/0000-0002-5530-6264)
- Franz Schilling (ORCID: https://orcid.org/0000-0001-5239-4628)
- Frits H. A. van Heijster (ORCID: https://orcid.org/0000-0002-0814-5189)
- Tristan Anselm Kuder (ORCID: https://orcid.org/0000-0001-6439-8124)
- Wolfgang Weber (ORCID: https://orcid.org/0000-0002-7854-4345)
- Jonathan Nadjiri (ORCID: https://orcid.org/0000-0003-0698-965X)
- Bangwen Xie
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0149
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00