Mapping of Neurometabolic Vulnerability in Acute Ischemic Stroke Using High-Resolution 3D MRSI

Motivation: Characterizing neurometabolic vulnerability to ischemia is essential for better stroke management but remains largely unexplored in patients. Goal(s): To map spatial neurometabolic vulnerability patterns in ischemic stroke using high-resolution 3D 1H-MRSI. Approach: We performed 3D 1H-MRSI scans using the SPICE technique (scan time: 8 minutes, resolution: 2×3×3 mm3, FOV: 240×240×72 mm3) on 105 acute ischemic stroke patients, with 21 follow-up scans. Results: Voxel-wise vulnerability index (VI) maps for N-acetylaspartate, creatine, choline, and lactate were obtained. Regional differences in neurometabolic vulnerability and dynamic changes over time were revealed. Incorporating neurometabolic VI data improved infarct prediction accuracy. Impact: Neurometabolic vulnerability maps obtained in acute stroke patients provide useful insights into cellular vulnerability patterns that could inform more effective stroke management.

Authors

Publication Details

Journal
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Published
2025-09-16
DOI
https://doi.org/10.58530/2025/0276
Primary Topic
Advanced MRI Techniques and Applications
Type
article
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article

Mapping of Neurometabolic Vulnerability in Acute Ischemic Stroke Using High-Resolution 3D MRSI

Hong Zhou, Tianyao Wang, Bin Bo, Rong Guo et al.
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Advanced MRI Techniques and Applications
article

Mapping of Neurometabolic Vulnerability in Acute Ischemic Stroke Using High-Resolution 3D MRSI

Hong Zhou, Tianyao Wang, Bin Bo, Rong Guo, Zhi‐Pei Liang, Parashkev Nachev, Ziyu Meng, Yudu Li, Yibo Zhao, Chang Xu, Li Yao, Wen Jin
article en

Abstract

Motivation: Characterizing neurometabolic vulnerability to ischemia is essential for better stroke management but remains largely unexplored in patients. Goal(s): To map spatial neurometabolic vulnerability patterns in ischemic stroke using high-resolution 3D 1H-MRSI. Approach: We performed 3D 1H-MRSI scans using the SPICE technique (scan time: 8 minutes, resolution: 2×3×3 mm3, FOV: 240×240×72 mm3) on 105 acute ischemic stroke patients, with 21 follow-up scans. Results: Voxel-wise vulnerability index (VI) maps for N-acetylaspartate, creatine, choline, and lactate were obtained. Regional differences in neurometabolic vulnerability and dynamic changes over time were revealed. Incorporating neurometabolic VI data improved infarct prediction accuracy. Impact: Neurometabolic vulnerability maps obtained in acute stroke patients provide useful insights into cellular vulnerability patterns that could inform more effective stroke management.

Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Openalex Percentile: Top 64%
Advanced MRI Techniques and Applications
DOISourceOpenAlex
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Mapping of Neurometabolic Vulnerability in Acute Ischemic Stroke Using High-Resolution 3D MRSI — Hong Zhou, Tianyao Wang, et al. · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2025) | TGRS Research Map | TGRS