Prediction of the mechanical properties of the myocardium from CMR clinical type protocol in acute lymphoblastic leukemia survivors.

Motivation: Doxorubicin-based chemotherapy entails dose-dependent cardiotoxicity that could be revealed by subtle changes in myocardium mechanical properties. Goal(s): To predict the mechanical properties in acute lymphoblastic leukemia (ALL) from previous established relationships to CMR parameters. Approach: Left ventricle stiffness, contractility and pressure were computed from mechanical models and their relationships to CMR parameters were established on ALL survivors' training data. Mechanical properties were predicted from CMR parameters on LLA survivors' test data. Results: We were able to predict mechanical properties from CMR clinical type protocol as confirmed by the agreement between our predicted mechanical parameters and echocardiographic measures. Impact: We proposed a useful method to quantify mechanical properties from CMR. The stiffness might unmask potential cardiac conditions not observable in resting condition. Thus, in combination with exercise CMR, this method could be applied to early diagnosis of cardiomyopathies.