Prognostic Utility of Left Atrial Strain to Predict Atrial Fibrillation in Hypertrophic Cardiomyopathy: Insights from the NHLBI HCM Registry
Motivation: Atrial fibrillation (AF) is a major driver of morbidity and mortality in hypertrophic cardiomyopathy (HCM). Single centre evidence suggested that left atrial (LA) strain may be used to identify patients at risk of AF. Goal(s): This study aimed to determine the prognostic utility of LA strain to predict new AF events in the world's largest HCM registry. Approach: Cardiovascular magnetic resonance data of 1,661 HCM patients was used to derive an optimal LA strain threshold, which was then validated in an independent cohort. Results: LA reservoir strain was identified as an independent predictor of AF, providing prognostic information beyond established risk factors. Impact: Our findings suggest that left atrial (LA) strain is an independent predictor of atrial fibrillation in patients with hypertrophic cardiomyopathy. Assessment of LA strain may thus improve prognostic risk assessment and clinical management in the future.
Authors
- Carolyn Yung Ho (ORCID: https://orcid.org/0000-0002-7334-7924)
- R Smillie (ORCID: https://orcid.org/0000-0003-2662-8675)
- Maximilian Fenski (ORCID: https://orcid.org/0000-0002-5943-305X)
- Betty Raman (ORCID: https://orcid.org/0000-0002-1239-9608)
- Yi Jie Gifford Tan
- Paul Kolm (ORCID: https://orcid.org/0000-0003-2653-5452)
- Milind Y. Desai (ORCID: https://orcid.org/0000-0003-0010-9797)
- Hugh Watkins (ORCID: https://orcid.org/0000-0002-5287-9016)
- Christopher M. Kramer (ORCID: https://orcid.org/0000-0003-2057-7731)
- William S. Weintraub (ORCID: https://orcid.org/0000-0002-5384-5571)
- Michael Jerosch‐Herold (ORCID: https://orcid.org/0000-0001-9018-6731)
- Johan Fredrik Brekke
- Niklas Beyhoff (ORCID: https://orcid.org/0000-0001-9140-2336)
- Patrice Desvigne‐Nickens (ORCID: https://orcid.org/0000-0003-1073-641X)
- John Dimarco
- Stefan Neubauer (ORCID: https://orcid.org/0000-0001-9017-5645)
- Sarahfaye Dolman (ORCID: https://orcid.org/0000-0003-3651-9069)
- Raymond Y. Kwong (ORCID: https://orcid.org/0000-0001-8212-0759)
- Christina Botrous (ORCID: https://orcid.org/0000-0001-6289-7050)
- Dong-Yun Kim (ORCID: https://orcid.org/0000-0002-3196-9936)
- Owen P. Agnel
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0359
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00