Mesoscale T2*-weighted MRI of the human cerebellum at 10.5 Tesla: initial experience
Motivation: There is an increasing interest in pursuing ultrahigh resolution human cerebellum MRI at ultrahigh field capitalizing on the increased SNR and CNR. Goal(s): To demonstrate the feasibility and utility of mesoscale T2*-weighted cerebellum MRI at 10.5T by synergizing various techniques. Approach: Data were collected at 0.4-mm isotropic resolution with tailored RF shimming, a custom high density head RF array, and fast motion-robust multi-echo 3D EPI. SWI, quantitative R2* and local field maps were obtained. Results: Our approach produced high quality images, delineating fine cerebellar architecture with improved SNR and contrast. Impact: The demonstrated feasibility and utility of motion-robust mesoscale multi- echo EPI in humans at 10.5T may shed light on future optimal implementation of anatomical T2*-weighted cerebellum MRI at ultrahigh field, paving the way for future neuroscience applications.
Authors
- Gregor Adriany (ORCID: https://orcid.org/0000-0002-6428-9005)
- Matt Waks (ORCID: https://orcid.org/0000-0003-1743-8888)
- Russell Lagore (ORCID: https://orcid.org/0000-0003-1950-1828)
- Yiğitcan Eryaman (ORCID: https://orcid.org/0009-0006-7880-9872)
- Lance DelaBarre
- Gülin Öz (ORCID: https://orcid.org/0000-0002-5769-183X)
- Alexander Bratch
- Edward J. Auerbach (ORCID: https://orcid.org/0000-0003-4553-1545)
- Kâmil Uǧurbil (ORCID: https://orcid.org/0000-0002-8475-9334)
- Xiaoping Wu (ORCID: https://orcid.org/0000-0001-6021-9088)
- Andrea Grant (ORCID: https://orcid.org/0000-0002-1553-596X)
- Jiaen Liu (ORCID: https://orcid.org/0000-0001-7968-8431)
- Peter van Gelderen (ORCID: https://orcid.org/0000-0001-8117-8270)
- Alireza Sadeghi Tarakameh
- Shuxian Qu
- Jacco de Zwart
- Jeff H. Duyn
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0270
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00