Age-related Changes in Brain Metabolites in Early Infancy: A Cross-Sectional Analysis of the First HBCD Data Release
Motivation: Neurometabolite concentration changes in the first few months after birth have not been studied in a large cohort. Goal(s): To assess early neurochemical development in a large cohort of 0-8 month-old infants by analyzing all available data in the first MRS data release of the HEALthy Brain and Child Development study ("HBCD"). Approach: Linear combination modeling will quantify 14 neurometabolites in this cross-sectional population. Statistical analyses will test for significant relationships between metabolite levels, birth-age and gestational age. Impact: Identifying changes in neurochemical levels in the first few months after birth in a large cohort for the first time will help deepen our understanding of the various roles these chemicals play in neurodevelopment.
Authors
- Ralph Noeske (ORCID: https://orcid.org/0000-0002-6193-366X)
- Muhammad G. Saleh (ORCID: https://orcid.org/0000-0001-6921-112X)
- Helge J. Zöllner (ORCID: https://orcid.org/0000-0002-7148-292X)
- Borjan Gagoski (ORCID: https://orcid.org/0000-0003-3777-2621)
- Aaron T. Gudmundson (ORCID: https://orcid.org/0000-0001-5104-0959)
- Georg Oeltzschner (ORCID: https://orcid.org/0000-0003-3083-9811)
- William T. Clarke (ORCID: https://orcid.org/0000-0001-7159-7025)
- Zahra Shams (ORCID: https://orcid.org/0000-0002-0311-0665)
- Richard A.E. Edden (ORCID: https://orcid.org/0000-0002-0671-7374)
- Steve C. N. Hui (ORCID: https://orcid.org/0000-0002-1523-4040)
- Saipavitra Murali‐Manohar (ORCID: https://orcid.org/0000-0002-4978-0736)
- Yulu Song (ORCID: https://orcid.org/0000-0002-4416-7959)
- Christopher W. Davies‐Jenkins (ORCID: https://orcid.org/0000-0002-6015-762X)
- Jessica L. Wisnowski (ORCID: https://orcid.org/0000-0002-4039-8362)
- M. Dylan Tisdall (ORCID: https://orcid.org/0000-0002-0454-3112)
- Gizeaddis Simegn
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0439
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00