Preliminary findings from 4D-flow MRI on left heart hemodynamics in Chronic Obstructive Pulmonary Disease: The SPIROMICS Heart Failure Study
Motivation: Chronic obstructive pulmonary disease (COPD) is associated with heart failure. Goal(s): To investigate hemodynamic changes in the left-sided heart chambers using 4D-flow MRI and evaluate their correlation with COPD severity. Approach: We analyzed fifty 4D-flow MRI cases from the SPIROMICS HF study. Results: A significant negative correlation was found between the energy loss to kinetic energy ratio and forced vital capacity in the left ventricle (r = -0.37, p =0.014). Maximum velocity in the aorta also negatively correlated with residual lung volume (r = -0.31, p = 0.035), indicating impaired left heart hemodynamics in COPD patients. Impact: Our findings emphasized using 4D-flow MRI as a noninvasive method for evaluating heart function in COPD patients. This opens new research into therapies targeting heart-lung interactions, improving outcomes that were previously unattainable.
Authors
- Melika Shafeghat (ORCID: https://orcid.org/0000-0001-6758-4029)
- J. Paul Finn (ORCID: https://orcid.org/0000-0002-4534-7572)
- Joyce Schroeder (ORCID: https://orcid.org/0000-0002-7451-4886)
- Sachin Jambawalikar (ORCID: https://orcid.org/0000-0003-1839-6798)
- Igor Barjaktarević (ORCID: https://orcid.org/0000-0002-8096-0858)
- Wei Shen (ORCID: https://orcid.org/0000-0003-4838-4923)
- Meilan Han
- Steven G. Lloyd (ORCID: https://orcid.org/0000-0001-6843-0224)
- Michael Markl (ORCID: https://orcid.org/0000-0002-7686-1128)
- R. Graham Barr
- Prachi Agarwal (ORCID: https://orcid.org/0000-0002-4439-6970)
- Martine R Prince
- Oliver Wieben (ORCID: https://orcid.org/0000-0002-7931-1930)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3311-0818)
- Bharath Ambale‐Venkatesh (ORCID: https://orcid.org/0000-0002-2330-2373)
- Kristina L. Buschur
- Tim Houston
- Jens Vogel‐Claussen (ORCID: https://orcid.org/0000-0001-5595-6948)
- David Dushfunian (ORCID: https://orcid.org/0000-0002-0628-1961)
- João L. M. P. de Lima (ORCID: https://orcid.org/0000-0002-0135-2249)
- James Carr
- David Bluemke
- Christopher B. Cooper
- Roy W. Pain
- Dalane W Kitzman
- M. Backman (ORCID: https://orcid.org/0000-0002-4818-5978)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3666
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00