Multi-parametric MRI study of stroke in Model Aged Hypertensive Rats
Motivation: The synergistic effects of hypertension and aging on brain morphology is described and the evolution patterns of cerebral atrophy from spatial and temporal perspectives using Rat stroke model. Goal(s): Using non-invasive MRI techniques, we have investigated changes in the brain of 18-month-old spontaneously hypertensive (SHR) rats following a 30-minute transient middle cerebral artery occlusion (tMCAO) or SHAM for 8 weeks. Approach: Using multi-parametric MRI data to access the treatment efficacy Results: Our results demonstrate that treatment of stroke with Angiotensin type 2 receptor (AT2R) agonist reduced lesion volume compare to non-treated group. Impact: The C21-treatement improve outcome.
Authors
- Bindu Pillai
- Abdulkarim Alshammari (ORCID: https://orcid.org/0009-0008-6318-4341)
- Pradip Kumar Kamat (ORCID: https://orcid.org/0000-0002-0376-2284)
- Asamoah Bosomtwi
- Susan Fagan
- Roxan Ara (ORCID: https://orcid.org/0009-0001-0581-640X)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3653
- Primary Topic
- Brain Tumor Detection and Classification
- Type
- article
- Field-Weighted Citation Impact
- 0.00