Impaired mitochondrial energy metabolism related to astrocyte in the brain of Alzheimer’s disease

Motivation: The pathogenesis of Alzheimer's disease (AD) remains unclear. Recently, abnormalities in brain energy metabolism associated with AD have attracted attention. Goal(s): This study aimed to gain insight into the background mechanisms of abnormal brain energy metabolism associated with AD pathology. Approach: We performed proteomic analysis in brain tissues derived from AD patients and AD model mice, and in vivo metabolic assessment with 1H MRS and hyperpolarized [1-13C]pyruvate MRS in AD model mice. Results: Impaired mitochondrial energy metabolism related to astrocyte was implied in the brain of AD patients and AD mouse model. Impact: This study provides insights into impaired mitochondrial energy metabolism associated with AD. Hyperpolarized [1-13C]pyruvate MRS detected hippocampal metabolic changes in AD mouse model at early pathological stages, and is expected to be applied to pathological studies of AD.