Evaluating 3D-EPI and FLASH-based multi-parameter mapping in temporal lobe epilepsy: a traveling head study
Motivation: Drug-resistant temporal lobe epilepsy (TLE) can benefit from quantitative magnetic resonance imaging (MRI) such as multi-parameter mapping (MPM) for improved identification of epileptogenic regions. Traditional MPM protocols are often too time-consuming for clinical use. Goal(s): This study evaluates the reproducibility of time-efficient 3D-EPI MPM sequences against traditional FLASH to assess their clinical applicability in TLE. Approach: Four subjects were scanned across five 3T MRI sites with both 3D-EPI and FLASH. Qualitative and quantitative analysis was conducted for comparison. Results: 3D-EPI MPM demonstrated similar reproducibility to FLASH, suggesting it could be a faster alternative for MPM imaging in clinical TLE. Impact: We demonstrate the potential of using 3D-EPI for efficient MPM acquisition for characterising regional differences in epileptogenic regions. However, it´s unclear whether our results translate to detecting subtle abnormalities in clinical application due to, e.g. reduced spatial resolution of 3D-EPI.
Authors
- Difei Wang (ORCID: https://orcid.org/0000-0002-7983-2648)
- Nikolaus Weiskopf (ORCID: https://orcid.org/0000-0001-5239-1881)
- Shaihan Malik (ORCID: https://orcid.org/0000-0001-8925-9032)
- Rüdiger Stirnberg (ORCID: https://orcid.org/0000-0001-7021-1063)
- Francisco J. Fritz (ORCID: https://orcid.org/0000-0002-6506-6508)
- Kerrin Pine (ORCID: https://orcid.org/0000-0002-2486-2970)
- Martina F. Callaghan (ORCID: https://orcid.org/0000-0003-0374-1659)
- Luke Edwards (ORCID: https://orcid.org/0000-0002-8320-7298)
- Philippa Bridgen (ORCID: https://orcid.org/0009-0008-8051-8139)
- Laurin Mordhorst (ORCID: https://orcid.org/0000-0001-9870-3916)
- Zihan Ning (ORCID: https://orcid.org/0000-0002-9692-1976)
- David Leitão (ORCID: https://orcid.org/0000-0001-5853-8602)
- Siawoosh Mohammadi (ORCID: https://orcid.org/0000-0003-1311-9636)
- David W. Carmichael (ORCID: https://orcid.org/0000-0001-9972-0718)
- Nina Lüthi
- Tony Stöcker
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/3547
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00