Decreased cholinergic neuronal firing in a mouse model of temporal lobe seizures with impaired consciousness
Our findings provide direct evidence that focal limbic seizures are associated with decreased cholinergic neuronal firing in brainstem arousal nuclei, linking subcortical suppression to cortical impairment. Further exploration of these pathways promises a deeper understanding of ictal unconsciousness and potential novel treatments for people with epilepsy.
Authors
- Marcus Valcarce‐Aspegren
- Hal Blumenfeld (ORCID: https://orcid.org/0000-0003-0812-8132)
- Jiayin Qu (ORCID: https://orcid.org/0009-0006-5277-8422)
- Lim‐Anna Sieu (ORCID: https://orcid.org/0000-0002-7224-3672)
- S. Liu (ORCID: https://orcid.org/0000-0002-6318-6469)
- Waleed Khan (ORCID: https://orcid.org/0000-0001-6335-4808)
- D. J. Lee
- Jiayang Liu (ORCID: https://orcid.org/0000-0002-2337-0093)
- Alvaro Duque (ORCID: https://orcid.org/0000-0002-5086-5438)
- Patrick Paszkowski
- Sarah C. McGill
Institutions
- Yale University (US)
- Beijing Tsinghua Chang Gung Hospital (CN)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-09-16
- DOI
- https://doi.org/10.1111/epi.18625
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00