Hyperpolarized [1-13C]pyruvate to [1-13C]lactate Conversion Rate with mpMRI to Distinguish Pathologically Aggressive Prostate Cancer
Motivation: There is a pressing clinical need to distinguish aggressive from indolent prostate cancer (PCa). Goal(s): This study's objective was to quantify the capability of Hyperpolarized (HP) [1-13C]pyruvate magnetic resonance imaging (MRI) to distinguish aggressive from indolent PCa. Approach: A prospectively enrolled patient cohort underwent 3T multiparametric 1H/HP13C MRI followed by prostatectomy and whole-mount histopathology. Multivariate logistic regression was performed to classify lesions. Results: Statistically significant differences for imaging parameters were observed between low-grade and high-grade PCa. The multivariate model including kPL, ADC, and DCE enhancement slope (ES) predicted aggressive disease with a ROC area under curve = 0.93. Impact: There is a pressing clinical need to distinguish aggressive from indolent prostate cancer (PCa). Hyperpolarized [1-13C]pyruvate magnetic resonance imaging in combination with 1H multiparametric MRI has demonstrated potential to identify aggressive disease with high accuracy.
Authors
- Rosalie Nolley (ORCID: https://orcid.org/0009-0004-7269-5443)
- Renuka Sriram (ORCID: https://orcid.org/0000-0003-3505-2479)
- Romelyn Delos Santos
- John V. Kurhanewicz (ORCID: https://orcid.org/0000-0002-3544-5339)
- Jeffry Simko
- Daniel B. Vigneron (ORCID: https://orcid.org/0000-0001-5795-8699)
- Peder E. Z. Larson (ORCID: https://orcid.org/0000-0003-4183-3634)
- Robert Bok (ORCID: https://orcid.org/0000-0003-1737-9056)
- Jeremy W. Gordon (ORCID: https://orcid.org/0000-0003-2760-4886)
- Rahul Aggarwal (ORCID: https://orcid.org/0000-0001-7003-7982)
- Matthew R. Cooperberg (ORCID: https://orcid.org/0000-0003-4339-6685)
- Matthew Gibbons (ORCID: https://orcid.org/0000-0003-4108-6157)
- Susan M. Noworolski (ORCID: https://orcid.org/0000-0003-1609-2790)
- Hsin-Yu Chen (ORCID: https://orcid.org/0000-0001-6268-5023)
- Donna M. Peehl (ORCID: https://orcid.org/0009-0003-8592-7242)
- James Slater
- Peter Carroll
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0809
- Primary Topic
- Advanced NMR Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00