Assessment of Slow Flow in the Brain using SCIMI and q-aMRI on a High-Performance Gradient System: Comparison of Phase and Magnitude-based Methods
Motivation: The physiology and function of slow flows in the brain parenchyma is poorly understood and remains an on-going research subject. Goal(s): To compare displacement fields of the simultaneous coherent and incoherent motion imaging (SCIMI) method (phase-based) and the 3D quantitative amplified MRI (q-aMRI) method (magnitude-based) with the view to jointly validate both methods. Approach: Displacement fields (Lagrangian perspective) of SCIMI and q-aMRI acquisitions were obtained from four healthy volunteers and compared using correlation and Bland Altman (BA) plots. Results: Correlation r2 as high as 0.93 and mean differences in BA analyses as low as 0 were observed between SCIMI and q-aMRI displacement estimations. Impact: This study independently compared the measured displacement fields due to brain parenchymal fluid flow obtained from the SCIMI and q-aMRI methods and the correlation of both estimations, thereby validating both methods and providing deeper insights for applications in neurodegenerative pathologies.
Authors
- Samantha J. Holdsworth (ORCID: https://orcid.org/0000-0002-2929-1169)
- Chitresh Bhushan (ORCID: https://orcid.org/0000-0002-2935-2515)
- Maureen N. Hood (ORCID: https://orcid.org/0000-0002-6111-9262)
- John C. Warner (ORCID: https://orcid.org/0000-0002-3734-8903)
- Thomas Foo (ORCID: https://orcid.org/0000-0002-9016-1005)
- Itamar Terem (ORCID: https://orcid.org/0000-0002-6544-9138)
- Angeliki Pollatou (ORCID: https://orcid.org/0000-0003-0379-4187)
- Vincent B. Ho (ORCID: https://orcid.org/0000-0001-6603-8384)
- Luca Marinelli (ORCID: https://orcid.org/0000-0001-7775-5952)
- Robert Shih (ORCID: https://orcid.org/0000-0001-8316-2061)
- Nastaren Abad (ORCID: https://orcid.org/0000-0002-7020-0492)
- Isabelle Heukensfeldt Jansen (ORCID: https://orcid.org/0009-0004-6490-4882)
- Elizabeth Metzger
- Afis Ajala (ORCID: https://orcid.org/0000-0002-1763-0274)
- J. Kevin DeMarco (ORCID: https://orcid.org/0000-0001-6434-0010)
- Kawin Setsompop (ORCID: https://orcid.org/0000-0003-0455-7634)
- Gail Kohls
- Sonja Skeete
- H Doug Morris
- Haymanot Yalewayker
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0473
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00