Enhancing OGSE Image Quality Using Deep Learning and Distortion Correction for the Estimation of Smaller Cellular Structures at 7T

Motivation: High-resolution imaging of small cellular structures remains a challenge in clinical MRI due to limitations in existing diffusion sequences and hardware. Goal(s): The study aims to improve image quality using deep learning (DL) and distortion correction (DC) techniques, applying them to MR cell size imaging at 7T. Approach: The IMPULSED model was applied using PGSE and OGSE sequences at 7T, incorporating DC and DL methods for image enhancement, and the clinical feasibility was assessed. Results: The improved images demonstrated clearer structural details, with DL significantly reducing noise and DC effectively correcting distortion, offering potential for finer microstructural analysis. Impact: This study enables higher-resolution MR imaging of small cellular structures at 7T using deep learning (DL) and distortion correction (DC), potentially enhancing diagnostic capabilities in neurology and oncology, and encouraging further exploration of microstructural analysis in clinical practice.