Four-Dimensional, Ferumoxytol-Enhanced MUSIC in a Single Breath-Hold: Technical Feasibility in Structural Heart Disease
Motivation: Practical drawbacks of 4D and 5D MR techniques for imaging of structural heart disease pose significant barriers to the widespread adoption of multi-dimensional approaches in clinical practice. Goal(s): To implement 4D-MUSIC in a single breath-held acquisition with immediate inline reconstruction, and to assess its feasibility in adult patients. Approach: A single breath-held 4D cardiac phase-resolved (BH 4D-MUSIC) ferumoxytol-enhanced MRI pulse sequence was implemented and its feasibility in adult patients with structural heart disease was evaluated. Results: BH 4D-MUSIC was successfully acquired and reconstructed inline in all patients, with breath hold durations range of 17-24 seconds and 8-16 cardiac phases. Impact: Ferumoxytol-enhanced single breath-held 4D MUSIC is feasible, extending its potential applications beyond children under anesthesia to adults and older children with cardiovascular disease.
Authors
- J. Paul Finn (ORCID: https://orcid.org/0000-0002-4534-7572)
- Xiaodong Zhong (ORCID: https://orcid.org/0000-0001-8355-5279)
- Kim‐Lien Nguyen (ORCID: https://orcid.org/0000-0002-8854-2976)
- Takegawa Yoshida (ORCID: https://orcid.org/0000-0002-2767-7009)
- Ning Jin (ORCID: https://orcid.org/0000-0002-5828-6908)
- Sixiong Shi
- Arash Bedayat (ORCID: https://orcid.org/0000-0001-8769-0224)
- Fei Han (ORCID: https://orcid.org/0000-0002-1598-9048)
Publication Details
- Journal
- Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
- Published
- 2025-09-16
- DOI
- https://doi.org/10.58530/2025/0402
- Primary Topic
- Wireless Power Transfer Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00