Role of Caudate Nucleus Volume in Mild Cognitive Impairment Induced by Occupational Aluminum Exposure

Motivation: Long-term occupational exposure to aluminum (Al) may contribute to mild cognitive impairment (MCI). However, the specific neural mechanism is still unclear. Goal(s): Aimed to investigate the neurobiological mechanisms behind Al-induced MCI. Approach: We collected clinical, cognitive scoring, and MRI data from workers with occupational Al exposure and normal individuals, comparing gray matter volume differences among groups and their correlation with cognition. Results: There were differences in the volume of the bilateral caudate nucleus (CAU) among the three groups, with the smallest volume observed in patients with Al-induced MCI. The volume of the bilateral CAU was correlated with cognitive scores. Impact: Occupational Al exposure may contribute to cognitive impairment, linked to bilateral CAU atrophy. Declines in memory function may further reduce cognitive ability by affecting CAU volume. Study offers insights into neural mechanisms underlying cognitive impairment related to occupational Al exposure.